Should meta-analyses trump observational studies?
نویسندگان
چکیده
منابع مشابه
Tools for health care decision making: observational studies, modeling studies, and network meta-analyses.
Comparative effectiveness research incorporates study designs extending beyond the randomized controlled trial (RCT) [1], which is the touchstone for demonstrating therapeutic efficacy. The litany of RCT flaws is often recited: not real world, not real patients, not real settings, not available, not timely, and not affordable. Although not every RCT is well designed, there are established narra...
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BACKGROUND Diagnostic reviews often include the sensitivity/specificity results of individual studies. A problem occurs when these data are pooled because the correlation between sensitivity and specificity is generally strongly negative, causing overestimation of the pooled results. The diagnostic odds ratio (DOR), defined as the odds of true positives vs. that of false positives, may avoid th...
متن کاملAntioxidant enzyme activity and coronary heart disease: meta-analyses of observational studies.
Controversial data exist concerning the relation between the activities of scavenger antioxidant enzymes and coronary heart disease (CHD) risk. The authors report updated meta-analyses of studies assessing the activities of 3 antioxidant enzymes--glutathione peroxidase, superoxide dismutase, and catalase--and CHD risk. Computer-based and manual searches of the relevant literature from January 1...
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ژورنال
عنوان ژورنال: The American Journal of Clinical Nutrition
سال: 2012
ISSN: 0002-9165,1938-3207
DOI: 10.3945/ajcn.112.055111